Depends, but drugs generally fall into 3 catagories. Uppers, downers and phychedelics, just pay attention to the person's eyes, mouth/jaw and how they're acting in general.
-lack of sleep at the right time and excessive sleep during the day
-red eyes
-shifty behavior
-inattention to personal hygiene like brushing teeth
-lying unnecessarily especially on plans and where the person was/has been
-going thru money like it is water or grows on trees
-hanging out with and defending "friends" normal people would question or avoid
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