Pigmentation and genetics?

fox · Jan 19, 2020

According to SNPedia the rs1426654(A) allele (light skin pigmentation) spread through the European population around 6,000 - 12,000 years ago. Both of the variants i inherited from my parents came back as A. Lets hear the suugo science and if you have your results please share.

https://www.snpedia.com/index.php/Rs1426654(A;A)
https://www.snpedia.com/index.php/Rs1426654

Arabsiyawi · Jan 19, 2020

Genes // Marker (SNP) // Genomic Position // Variants // Your Genotype
SLC24A5 // rs1426654 // 48426484 // A or G // A / G

Does "G/A" mean that I inherited both genes, the one for dark skin pigmentation and the other for light ?

fox · Jan 19, 2020

Alexis said:
Genes // Marker (SNP) // Genomic Position // Variants // Your Genotype
SLC24A5 // rs1426654 // 48426484 // A or G // A / G

Does "G/A" mean that I inherited both genes, the one for dark skin pigmentation and the other for light ?

Guessing you inherited two different variants from your parents.

Tbh I'm an absolute novice. Don't know too much. Let's see what the others have to say.

EDsomali · Jan 19, 2020

rs1426654 A-A for light skin G-A for mixed and G-G for dark.

rs16891982 G-G for light skin G-C for mixed and C-C for dark.

There are probably some Somali specific or cushtic specific alleles that effect skin colour but there hasnt been much research on it.

Western4Life · Jan 19, 2020

I have two A's but I am dark skin. Makes no sense.

Arabsiyawi · Jan 19, 2020

Western4Life said:
I have two A's but I am dark skin. Makes no sense.

We're somalis, that's why.

fox · Jan 22, 2020

Western4Life said:
I have two A's but I am dark skin. Makes no sense.

You're just a coconut :chrisfreshhah:

strawberrii · Jan 26, 2020

Alexis said:
Genes // Marker (SNP) // Genomic Position // Variants // Your Genotype
SLC24A5 // rs1426654 // 48426484 // A or G // A / G

Does "G/A" mean that I inherited both genes, the one for dark skin pigmentation and the other for light ?

You're heterozygous, having a copy of both alleles.

Apollo · Jan 26, 2020

@fox, @Western4Life, @Alexis and others,

The SNP mentioned above is just the strongest known de-pigmentation SNP. There are other pigmenting SNPs. They recently discovered some of them through research on Africans, South Asians, and Melanesians.

So you can still be brown to dark skin while carrying AA on rs1426654 because of those other pigmenting SNP underneath:

https://www.ncbi.nlm.nih.gov/pubmed/29025994

They even tested it out on mice and it had an effect:

Arabsiyawi · Jan 26, 2020

Apollo said:
@fox, @Western4Life, @Alexis and others,

The SNP mentioned above is just the strongest known de-pigmentation SNP. There are other pigmenting SNPs. They recently discovered some of them through research on Africans, South Asians, and Melanesians.

So you can still be brown to dark skin while carrying AA on rs1426654 because of those other pigmenting SNP underneath:

https://www.ncbi.nlm.nih.gov/pubmed/29025994

They even tested it out on mice and it had an effect:

Don’t understand any of this but AMAZING !

Pigmentation and genetics?

fox

31/12/16 - 04/04/20

Arabsiyawi

HA Activist.

fox

31/12/16 - 04/04/20

EDsomali

Western4Life

Arabsiyawi

HA Activist.

fox

31/12/16 - 04/04/20

strawberrii

#ArthurGang

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